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The most clinically relevant desmosomes are desmoglein 1 and 3 Desmoglein 1: Most abundant in superficial epidermal layers (stratum granulosum/corneum) Present in high concentrations in skin Found in lower amounts in mucosal tissues Desmoglein 3: Highly abundant in mucous membranes Present in deeper layers of epidermis (basal and lower spinous) but at lower levels than Dsg1 The Golden Rule: If Dsg 3 is involved, it is Pemphigus Vulgaris
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