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Further research identified oxidative stress as a key contributor to these alterations, as it induces the expression of small heterodimer partner, suppressing essential transcription factors for the transcription of insulin genes such as pancreatic and duodenal homeobox 1 (PDX-1) and musculoaponeurotic fibrosarcoma oncogene family A (MafA) [5,27]

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10.1016/j.abb.2008.10.011 [DOI] [PubMed] [Google Scholar] 40.Whatley SA, Curti D, Das Gupta F, Ferrier IN, Jones S, Taylor C, et al