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Gpx1 −/− mice showed decreased expression of gluconeogenic genes such as glucose-6- phosphatase ( G6pc ) and phosphoenolpyruvate carboxykinase ( Pepck ), increased glucose uptake by white gastric and diaphragm skeletal muscles through membrane docking of glucose transporter 4 (Glut4) upon Akt substrate of 160 kDa (As160) phosphorylation on Thr642 [pAS160(Thr642)], and enhanced insulin-induced oxidation β fibroblast cells [75]
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