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ROS, which include superoxide anion radicals, hydrogen peroxide, and hydroxyl radicals, can interact with membrane lipids and DNA to produce toxic metabolites containing lipid peroxides, carbonyls, and epoxides [37]
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In 2016, Novo Nordisk began clinical development of cagrilintide (originally designated AM833 or NN0174-0833), a long-acting amylin analog designed from the ground up for once-weekly dosing
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