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In patients with SLE, increased Trp degradation is significantly associated with high IFN-γ production and correlates with disease activity, suggesting that IDO1 may be one of the key factors influencing macrophage polarization-related pathogenicity in SLE (83) Shade:Daydream Coral https://img.lazcdn.com/g/p/d235ade3fdaffdd2db86c91268c19f88.jpg_720x720q80.jpg The multi-faceted role of NADPH in regulating inflammation in activated myeloid cells - PMC Reviv-C

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